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3D-EXPRESS

Built upon our core 3D-EXplore platform, 3D-EXpress is a translational ex-vivo program designed to rapidly test immuno-oncology and oncology therapeutics using 3D tumoroids created from fresh patient tumors. Our tumoroids are never dissociated, propagated, or reassembled.

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  1. ISOLATION AND CHARACTERIZATION OF FRESH TUMOR TISSUE

  2. CONVERSION INTO 3D TUMOROIDS

  3. POOLING OF TUMOROIDS TO OVERCOME TUMOR HETEROGEINITY

  1. ALIQUOTING OF TUMOROIDS AND CRYOPRESERVATION

  2. EX VIVO TREATMENT OF PRESELECTED TUMOROIDS WITH CANDIDATE THERAPIES

WHAT IS 3D-EXPRESS?

Select pre-characterized tumors in our existing biorepository to generate actionable data by assessing target binding, stromal penetration and tumor cell killing of your drug and drug combinations using high content confocal imaging while analyzing conditioned media for cytokine release to monitor treatment-mediated changes in the tumor immune microenvironment.

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Potential Tumor Selection Criteria:

  • Target Expression via TMA's
  • Immune Profile
  • Genetic Background
  • Tumor Histology
  • Patient Demographics
  • Clinical Information
  • Pathology Report
  • Time 0 Flow Cytometry Analysis

Rapidly & Reliably Test Therapeutic Efficacy Using Tumor Cell Killing & Immune Activation

  • Bispecifics
  • Antibodies
  • Cell Therapies
  • ADC's
  • Small Molecules
  • Oncolytic Viruses

Capabilities

High Content Imaging

Combining high content imaging of multiple fluorescent tags with advanced analytics enables us to quantify penetration, target binding, tumor cell killing and phagocytosis due to drug treatment.

Tumor Cell Killing

The tumor microenvironment consists of multiple cell types including tumor cells, immune cells and stroma. Nilogen's high-content 3D imaging system is capable of identifying tumor and non-tumor cells during our tumor killing assay and our proprietary analytics enables the quantitative analysis of cell killing in response to drug treatment.

Multiplex Cytokine Analysis

Cytokines including chemokines, interferons, interleukins, lymphokines, and tumor necrosis factors, are all produced by a broad range of cell types. Cytokines have a specific effect on the behavior of neighboring cells by modulating maturation, growth, and the responsiveness of particular cell populations.

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