TME BACKGROUND

Maintaining the Tumor Microenvironment

The tumor microenvironment (TME) is a dynamic space that is constantly adjusting to tumor growth including numerous processes that promote tumorigenesis. The interactions involve many different cell types found in the TME including tumor cells, fibroblasts, dendritic cells, TILs, macrophages and NK cells as well as many noncellular components including the ECM and signaling molecules. These components and the spatial distribution of tumor cells, immune cells and ECM are unique to individual patients and essential to tumorigenesis. Therefore, a full understanding of the effect of a drug on tumor growth depends on understanding the interplay of all the components of the TME.

nilogen TME process

Nilogen’s 3D-EXSM platform consists of fresh and intact tumoroids of standardized dimensions and an unaltered microenvironment capturing the intimate and dynamic interactions of the TME including tumor cells, fibroblasts, extracellular matrix (ECM), dendritic cells, tumor infiltrating lymphocytes (TILs), macrophages and natural killer (NK) cells.

tumor cell ex-vivo preparation for TME background

A Powerful Platform

Nilogen’s 3D-ScreenSM, 3D-EXploreSM and 3D-EXSM platforms maintain all aspects of the TME providing the most essential environment for drug discovery and development. This unique structure cannot be recreated or manipulated to evaluate drug response.

In our CLIA-certified labs utilizing cutting edge technologies and customizable correlative assays, Nilogen uses the complete TME to provide the most powerful assessment of drug effects from early stage drug development to comprehensive analysis of the effects of a drug and drug combinations. With our cost-effective 3D-EX technology you can identify drug targets, biomarkers and analyze drug efficacy to de-risk your drug development from bench to clinical trial.

A Powerful Platform

tumor cell ex-vivo preparation for TME background

Nilogen’s 3D-ScreenSM, 3D-EXploreSM and 3D-EXSM platforms maintain all aspects of the TME providing the most essential environment for drug discovery and development. This unique structure cannot be recreated or manipulated to evaluate drug response.

In our CLIA-certified labs utilizing cutting edge technologies and customizable correlative assays, Nilogen uses the complete TME to provide the most powerful assessment of drug effects from early stage drug development to comprehensive analysis of the effects of a drug and drug combinations. With our cost-effective 3D-EX technology you can identify drug targets, biomarkers and analyze drug efficacy to de-risk your drug development from bench to clinical trial.

nilogen tme technology icon

LEARN MORE FROM US

Find out more about all of Nilogen’s technologies and how we put the TME to work for drug development.